coronavirus Disease (Covid-19) that appear in Indonesia since the beginning of March 2020 has become a serious condition to all age groups, including teenager. Teenager is called age of transition, when biological and psychological development occurs. Covid-19 can affect the psychological development of adolescents, causing anxiety that can not be controlled. One of the factors that influence anxiety is knowledge.

Purpose: the purpose of this paper was to know the relationship between knowledge levels with anxiety levels in adolescents on the Covid-19 pandemic.

Method: the study utilized a descriptive analytic with total sampling design. Respondents in this paper were all students of XII class in Balikpapan Adventist Senior High School totaling 60 people. Data collection using knowledge questionnaire adopted from the WHO surveyand Hamilton Anxiety Rating Scale (HARS) questionnaire.

Result: there were 9 respondents (15%) with standard knowledge felt mild anxiety, 33 respondents (55%) with good knowledge felt mild anxiety, 4 respondents (6.6%) with standard knowledge felt moderate anxiety, 9 respondents (15%) with good knowledge felt moderate anxiety, 1 respondent (1.7%) with standard knowledge felt severe anxiety, 4 respondents (6.7%) with good knowledge felt severe anxiety. The results of the chi-square test obtained p-value of 0.135 < α (0,05).

Conclusion: There is no relationship between the level of knowledge and the level of anxiety in adolescents at Balikpapan Adventist High School.