This study aimed to investigate the anti-inflammatory effects of Kopasanda leaf (Chromolaena odorata L.) extracts against carrageenan-induced inflammation on white rats’ (Rattus novergicus) feet through intraplantar injections. The inflammation volumes were measured using a plethysmometer over an eight-hour period. Active compounds known to have anti-inflammatory functions, such as flavonoids, saponins, rriterpenoids, alkaloids, and tannins, were found. This experimental study used white rats, which were divided into negative (no treatment), positive (treated with diclofenac sodium), and treatment (treated with extract) groups with three replications each. Three concentration variations of the extract were given. The data were analysed using ANOVA on the variables, concentration variations, and exposure times. The result shows that the average inflammation volume in rats with no treatment increased from 0.23 to 0.70, while inflammation volumes in rats treated with diclofenac sodium and extracts returned to their normal levels at the end of the treatment period. There was a significant difference in the time period of treatment exposure (p = 0.000), no significant difference in the extract concentration variations (p = 0.298), and no significant difference in the interaction between time of exposure and dosages (p = 0.922). The Duncan Multiple Range Test (DMRT) shows that the three concentration variations have the same effect. This study concluded that Kopasanda leaf (Chromolaena odorata L.) extract has an anti-inflammatory effect comparable with commercial agents such as diclofenac sodium.